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Suh Ching Yang

Suh Ching Yang

Taipei Medical University, Taiwan

Title: Impaired homocysteine metabolism in patients with alcoholic liver disease in Taiwan

Biography

Biography: Suh Ching Yang

Abstract

Background: Impaired homocysteine metabolism plays an important role in alcoholic liver disease (ALD); however, there are limited data about its relationship with the risk and severity of patients with ALD in Taiwan.

Participants & Methods: To understand plasma homocysteine and related vitamin concentrations in patients with ALD in Taiwan, we recruited 50 male patients with ALD from Cathay General Hospital, with 49 age-and gender-matched healthy adults as the control group. The Institutional Review Board for Human Studies approved the study, and informed consent was obtained from all patients prior to blood collection.

Results: Significantly higher plasma homocysteine concentrations but lower folate concentrations were obtained from patients with ALD. In addition, patients with ALD showed a significant lower erythrocyte reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio but higher plasma thiobarbituric acid-reactive substance (TBARS) concentration, which indicated that oxidative stress was occurring in patients with ALD. A negative correlation between plasma folate and homocysteine was observed in all subjects. There was also a negative correlation between plasma homocysteine and the erythrocyte GSH/GSSG ratio which indicated impaired homocysteine metabolism may have disrupted the antioxidative status. In addition, patients in Child-Pugh class B and C showed higher plasma vitamin B12 concentrations than did patients without cirrhosis and patients in Child-Pugh class A.

Conclusion: These findings show that impaired homocysteine metabolism was observed in patients with ALD in Taiwan. In addition, the plasma vitamin B12 concentration may reflect the degree of liver injury.

Publications:

  1. J.R. Chen, Y.L. Chen, H.C. Peng, Y.A. Lu, H.L. Chuang, H.Y. Chang, H.Y. Wang, Y.J. Su, S.C. Yang*(2016) Fish oil reduces hepatic injury by maintaining normal intestinal permeability and microbiota in chronic ethanol-fed rats, Gastroenterology Research and Practice, 2016:4694726. doi: 10.1155/2016/4694726.
  2. W.C. Chiu, Y.L. Huang, Y.L. Chen, H.C. Peng, W.H. Liao, H.L. Chuang, J.R. Chen, S.C. Yang*(2015) Synbiotics reduce ethanol-induced hepatic steatosis and inflammation by improving intestinal permeability and microbiota in rats, Food and Function 6: 1692-1700.
  3. Y.L. Chen, H.C. Peng, Y.C. Hsieh, S.C. Yang* (2014) Epidermal growth factor improved alcohol-induced inflammation in rats, Alcohol 48:701-706.
  4. Y.L. Chen, H.C. Peng, S.W. Tan, C.Y. Tsai, Y.H. Huang, H.Y. Wu, S.C. Yang*(2013) Amelioration of ethanol-induced liver injury in rats by nanogold flakes, Alcohol 47:467-472.