Dr. Jing-Bo Wang
The Fourth Military Medical University, China
Title: A decline of LAMP- 2 predicts ursodeoxycholic acid response in primary biliary cirrhosis
Biography
Biography: Dr. Jing-Bo Wang
Abstract
Biochemical response to ursodeoxycholic acid (UDCA) in patients with primary biliary cirrhosis (PBC) is variable. We have previously reported that augmented expression of lysosome-associated membrane protein 2 (LAMP-2) was correlated with the severity of PBC. This study aimed to determine whether serum LAMP-2 could serve as a predictor of biochemical response to UDCA, which was assessed after 1 year of UDCA treatment in PBC patients by a retrospective analysis. We found that baseline of serum LAMP-2 level increased in PBC, especially in patients with stage III-IV (p=0.010) or TBIL >1mg/dL (p=0.014). The basal level of serum LAMP-2 was higher in non-responders than that in responders, but the difference was statistically insignificant. However, after UDCA treatment, the serum LAMP-2 level decreased prominently in the first 3 months, which was more obvious in responders. Further studies showed that the 35% decline of LAMP-2 level after treatment for 3 months could be stated as an indicator of UDCA response with the sensitivity of 62.9% and 63.5%, specificity of 75.0% and 64.1% based on Paris criteria and Barcelona criteria respectively. Together, a decline in LAMP-2 might be a prognostic indicator to predict the response to UDCA in patients with PBC.
