Dr. Vani Malhotra
PGIMS, India
Title: Hepatitis B Infection During Pregnancy –Experience At Tertiary Care Centre Of North India
Biography
Biography: Dr. Vani Malhotra
Abstract
Aim: The aim was to investigate the seroprevalance of hepatitis B surface antigen (HbsAg) in pregnant women. Material & Methods: Fifteen thousand pregnant women were evaluated using history, examination and tested for serum HbsAg using commercial enzyme immunoassay kits. For HbsAg positive women, detailed biochemical evaluation including liver function tests, ultra sonogram abdomen and complete hepatitis B profile including HbeAg, HbeAb, IgM Anti HbC and HBV DNA analysis was also done by polymerase chain reaction (PCR). Results: Of 15,000 women studied, 52 tested positive for HbsAg. Of these 52 women, 8 presented with acute hepatitis and 44 had chronic hepatitis. The highest HbsAg positivity rate was seen in age group of 21-25 years. Assessment of risk factors revealed history of tattooing in 22 women. HbeAg and HBV DNA were highly positive in 12 patients. These were given tablet lamivudine to reduce the vertical transmission. Conclusion: Seroprevalance of HbsAg in antenatal women was found to be 0.34%.
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