Dr. Sen-Yung Hsieh
Chang Gung Memorial Hospital, Taiwan
Title: Impacts of platelets on the prognosis of patients with hepatocellular carcinoma
Biography
Biography: Dr. Sen-Yung Hsieh
Abstract
It has been a long-term enigma why Hepatocellular Carcinoma (HCC) runs a relatively lower rate of systemic metastasis and metastatic cancer which is rarely seen in the liver with cirrhosis. Most HCC occurs in cirrhotic livers, which are characterized by thrombocytopenia. Platelets contain not only hemostatic factors but also tremendous kinds of factors including bioactive metabolites (throboxane A2, adenosine, serotonin, thrombin), cytokines/chemokines (TGF-ï¢1, IL-1, CCL5, IL-8), and growth factors (PDGFs, HGF, EGF, IGF-1, VEGF) playing crucial roles in hemostasis, wound healing and tissue regeneration. On the other hand, platelets may also exert harmful effects by facilitating inflammation and tumor progression. In this presentation, the impact of platelets, particularly cirrhosis and thrombocytopenia, on the prognosis of HCC will be discussed.
