Dr. Sen-Yung Hsieh
Chang Gung Memorial Hospital, Taiwan
Title: The cirrhosis micro-environment and hepato-carcinogenesis
Biography
Biography: Dr. Sen-Yung Hsieh
Abstract
Hepatocellular carcinomas (HCC) are unique among all human cancers for its unusual cultivating cirrhosis microenvironment. More than 80% of HCC develop in cirrhotic livers with a propensity to multifoci, unusually high tumor vascularity, high recurrence, high local invasion and relatively systemic tumor dissemination and relatively resistance to cytotoxic chemo and molecular target therapies. These unique features contribute to very dismal outcomes of patients with HCC. Cirrhosis is not only a disease of the liver but also exerts greatly changes in the general physiology of the body which might play significant roles in the development and progression of liver tumors. However, little has been known why HCC prefers developing in cirrhotic liver, how cirrhotic liver fosters HCC development and progression, and how the tumor progression and dissemination are orchestrated by the unique systemic cirrhosis micro environment. This workshop will focus on updating our knowledge on the roles of the cirrhosis local and systemic microenvironment in hepatocarcinogenesis, tumor progression and clinical outcomes.
