Sevtap Aydin has completed his PhD from Hacettepe University. She is an Associate Professor at Hacettepe University, Pharmaceutical Toxicology Department since 2013. She has 22 publications in reputed journals. She has 242 citations for her publications. She is the Board Member of Turkish Society of Toxicology and FABAD (Society of Pharmaceutical Sciences of Ankara). She has good experiences in the field of oxidative stress, cell toxicity, genotoxicity, immunotoxicty, phenolic compounds and toxins.
Aflatoxins (AFs), the secondary metabolites produced by species of naturally occurring Aspergilli, are commonly found in food such as cereals, dried fruits and juice, wine, beer, and spices. They are primary hepatotoxic and are well-known human carcinogens based on sufficient evidence from human studies. AFs are one of the environmental risk factors in the pathogenesis of HCC. There is a risk for the progressing Hepato Cellular carcinoma (HCC) in the chronic hepatitis caused by hepatitis virus which is an important health problem in all over the world. Chronic Hepatitis B (CHB) patients are at increased risk of cirrhosis, hepatic failure, and HCC. This study was designed to determine the serum aflatoxin B1 (AFB1), aflatoxin B2 (AFB2), aflatoxin G1 (AFG1), and aflatoxin G2 (AFG2) concentrations using the high pressure liquid chromatography (HPLC) in the CHB patients with or without cirrhosis and HCC, and the healthy controls in Balikesir, Turkey. The mean AFB1 and total AF levels in the CHB patients without HCC and cirrhosis were found to be statistically higher than the healthy controls. The mean AFB1 and total AF levels in the CHB patients with HCC were found to be statistically higher than the CHB patients with or without cirrhosis. The results suggest that the CHB patients exposed to AFs are at risk for developing HCC, which might be prevented by reducing consumption of the AF contaminated foods. The AF levels should be determined in susceptible patients for human health.
Anamaria Orza focuses primarily on the area of development of innovative architectural nano camposites for biomedical applications. Prior to her arrival at Emory in the fall of 2013, she served as a Postdoctoral researcher at the Center for Integrative Nanotechnology Sciences at the University of Arkansas at Little Rock. She has been recognized as a European Union fellow, receiving her PhD in Chemistry from Babes Bolyai University, Romania and working in close collaboration with Liverpool University, United Kingdom. She has authored and co-authored 2 patents and over 32 papers in leading journals and at leading international conferences in the field (with over 170 citations) and 2 book chapters in the fields of Applied Nanotechnology in Cancer Research and Tissue Engineering.
In this study, we report on the synthesis and characterization of shaped iron oxide core palladium shell (Fe2O3-Pd) as three-modality image agents in magnetic resonance imaging (MRI), computed tomography (CT) and photoacoustic (PAT) imaging. Four shapes were synthesized such as: triangular plates, tetrapods, pyramidal structures and pentagon shaped nanoparticles. We report for the first time their synthesize using an original approach by uniformly fusing multiple components and by controlling their structural (i.e., size, shell thickness, dimer shape) and physical characteristics (i.e., optical, and acoustic). To confer enhanced properties for efficient targeted capability, the surface of the nanoparticles was modified with (i) the amphiphilic diblock polymer and (ii) functionalized with the ligands targeting transferrin receptor (Tr). As a result, the newly created shaped nanoparticles were characterized via different optical and imaging techniques (HR-TEM, STEM, XPS, EDX, Z-potential, UV-VIS). We show that the shaped Fe2O3-Pt are stable and biocompatible in given Fe concentrations range and display shaped control MRI/CT/PAT attenuation intensity. The attenuation intensity subsequently decreases as follows: tetrapods>pyramidal>pentagons>triangular plates. Moreover, these shaped nanoparticles enable targeting imaging of hepatocarcinoma tumor cells that have a high expression of the transferrin receptor. These findings conclude that the designed Fe2O3-Pd are promising contrast agents for targeted MRI/CT/PAT molecular imaging. rnrn